I'm no techy, but in my experience, you won't lose anything from Chrome.
However, I have found that if you play a game in a different browser, then go back to your original one, you sometimes lose the game settings, and have to re-do them.
As an aside, you will probably HAVE to use something different to Chrome soon anyway, (for game play at least), as all support for Chrome's NPAPI Flashplayer will stop in September, and Chrome users will be left to play using Pepperflash, which as we all know, is virtually impossible for most people to play with, due to the lag when clicking the mouse (something I'm currently having a long discussion with WGT Customer Service about)
Plenty of other options available to try, and some may work better for you that others, so worth downloading a few and experimenting a bit.
Steve