It depends on what you're trying to do. If you're trying to clear your browser cache, click on Clear Browsing Data, uncheck everything except "empty the cache " and click the clear browsing data button.
As a rule, you don't really need to be in Settings unless you want to clear that cache and you don't need to clear that cache on a regular basis. Some do but it isn't necessary unless you start seeing odd things happen while playing, like incomplete loads.