This happened last year when Flash was causing yellow cautions and white pages. The thread that dealt with it is here. From that thread courtesy of Infinito.....
"I have finished troubleshooting, it is combination of the beta version 2, and the video display drivers which I updated also. That did eliminate the crash.However, there is a serious bug in the memory requirements between the video display and flash player. The memory is not being released. Played on back 9 on Kiawah and it showed 1.5 giga bytes being used by FireFox. Hence, gone back to 10.1 beta version 1 and previous display drivers. "
This was over a year ago so it may not totally apply but might serve as a clue. Have you changed anything lately? By virtue of the fact that your settings aren't getting saved it does sound like a Flash issue.
When it happened to me my fix was to return to an earlier version of Flash (via Iron). Chrome automatically updates Flash so this may have happened without you knowing it and the newer version may be causing conflicts. FF also updates unless you specify it not to. This action is what makes Iron so effective because it stays with an older version of Flash and doesn't look for newer versions. Hope this helps, Tiff.