You have to consider the loft of the club that you are hitting. Elevation effects wedges and short irons somewhat less than mid or long irons. Adding or subtracting a yard for every 3 feet of elevation works very well for the mid irons I find.
Sometimes you can almost ignore the elevation change when hitting a wedge. A long iron - well I haven't figured those out to well my self. :P
Throw the wind and spin into the equation and you have some very complicated physics going on.
If you have yet to get a feel for elevation changes yet, try hitting with no spin on those shots until you do.. then experiment and find out how spin effects those shots
Oakmont #1 is a great place to practice this (just be sure to get it in the fairway! - jump into an unlimited play OAK front or 18 tourney and keep restarting the rounds till you feel like you have a handle on it.