Wee update...
Disconnected the hub and just started it normally on my laptop, without using the "ctrl" key.
Game started normally and without the heavy white border on the playing screen.
The image that comes up when in error is a golf ball, with driver behind and a red exclamation mark to the side.
So for now, I'll need to play without the other items being connected.
Scott - no difference with one or two monitors connected. Not sure why this started when all was good before. I even tried changing the screen resolution to see if that caused it - no real change, other than the exclamation mark stayed on the screen longer as it appeared to try and load something.